2008•The Chinese Journal of Modern Applied PharmacyRequires access
Photocytotoxic Effect of Hypericin Extract from Hypericum Performatum L.on MDA231 Human Mammary Carcinoma Cell Lines in vitro
Yang Ru-de
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Abstract
OBJECTIVE To investigate the photodynamic therapy (PDT) antitumoral effect in vitro of Hypericin extract form Hypericum performatum L. on MDA231 human mammary carcinoma cell lines. METHODS The cellular uptake of Hypericin extract was investigated by detecting endocellular fluorescence, and the antitumoral effect of Hypericin extract was assessed by light microscopy, MTT assay and DNA ladder gel electrophoresis. RESULTS Light-activated Hypericin extract has an obvious inhibition effect against MDA231 cells in vitro, and its efficacy was correlated to the concentration of Hypericin extract and the light energy. CONCLUSION Hypericin extract can obviously decrease the growth of mammary carcinoma cells. Hypericin extract should be a powerful natural photosensitizer and have a good prospect for further investigation.