Effects of dexmedetomidine on off-pump coronary artery bypass grafting

Objective To observe effect of dexmedetomidine on off-pump coronary artery bypass grafting( OPCABG). Methods 36 cases OPCABG were randomly divided into two groups: the dexmedetomidine group and control group. Group Ⅱ received induction of anesthesia with midazolam 0. 05- 0. 1 mg / kg,sufentanil 0. 5- 0. 8 μg / kg,etomidate 0. 15- 0. 3 mg / kg and rocuronium rromide 0. 8 mg / kg. Group Ⅰreceived dexmedetomidine 0. 5 μg / kg intravenously before induction of anesthesia,then keeping 0. 4 μg /( kg·h) until the end of surgery based on the group Ⅱ. Group Ⅱ received normal saline in the same manner. The mean arterial blood pressure( MAP) and heart rate( HR) in baseline( T0), after induction of anesthesia( T1),after intubation 1min( T2),after intubation 5 min( T3),the beginning of surgery( T4), saw the sternum( T5),off the sternum( T6),surgery end( T7) were recorded. The amounts of anesthetic drugs,postoperative eye opening,tracheal extubation time were recorded as well. Results MAP and HR in group Ⅰdecreased significantly than groupⅡin T2,T3,T4,T5,T6 time point( P 0. 05),Propofol and sufentanil dosage in group Ⅰwere significantly reduced than groupⅡ( P 0. 05). Eyes opening time and extubation time in Group Ⅰwere shorter than group Ⅱ( P 0. 05). Conclusion Dexmedetomidine might stabilize hemodynamics,reduce the dose of narcotic drugs and revive quickly and smoothly used in OPCABG surgery auxiliary anesthesia.