Effect of clonidine on hemodynamics by the lidocaine low epidural block

AIM To study the effect of clomicline on hemodynamics by the lidocaine low epidural block. METHODS Twenty patients were selected for this experiment, and randomly divided into two groups(ASA Ⅰ-Ⅱ). In A group (n=10), the placebo was administered at 90 min before anesthesia. In C group (n=10), the clonidine (3 μg·kg -1) was taken at 90 min before anesthesia. All patients were given luminal sodium before anesthesia. Epidural space was punctured in L 1-2 and epidural catheters were placed 3 cm toward head. 1.6% lidocaine was injected into epidural space (total volume 12 ml). SBP,DBP,HR,SPO 2,SV,SI,CO,CI,PAR,PAWP were monitored and recorded before medicine administered anesthesia, at 10 min, 20 min, 40 min after anesthesia, and at anesthesia end. RESULTS SBP,DBP,HR,SPO 2,SV,SI,CO,CI,PAR,PAWP before medicine administered anesthesia, at 10 min, 20 min, 40 min after anesthesia, and at anesthesia end were not significant difference in the two groups. CONCLUSION There was not significant effect of clonidine on hemodynamics when clonidine was administered at 90min before anesthesia in lidocaine low epidural block.