Survey on the Efficacy of Hepatitis B Vaccine in Taishan City

Objective To analyze the changes of hepatitis B virus marker (HBVM) in children in Taishan city since the introduction of hepatitis B vaccine into the expanded program of immunization in 1992. Method Stratifications including two villages and 138 children were drawn out by the method of multistage stratified sampling. HBsAg?anti-HBc and anti-HBs in the blood samples were detected by SPEIA method. Result In 2002, the immunization rate in children of 1～14 years old was 81.88%. 68.88% of children received the three-dose Hb vaccination. Their age distribution was 1～9 (81.52%) and 10～14 (69.56%) years old. The positive rates of HBsAg, anti-HBc and infection rate of HBV in children were decreased from 21.09%, 53.91% and 57.81% in 1992 to 4.35%, 22.46% and 34.78% in 2002, respectively. For the children of age 1～9, the positive rates of HBsAg, anti-HBc and HBV were decreased from 18.95%, 42.48%,45.10% in 1992 to 2.17%, 15.22%, 29.35% in 2002, respectively. After HBV vaccination, the positive rates of anti-HBs in children of age 1～3 and 4～14 was 28.57%～55.56% and 69.81%,respectively. Conclusion Since the launching of hepatitis B immunization program in 1992, HBV infection rate has been decreasing evidently, and the positive rate of anti-HBs has been increasing obviously. And the society is benefit from this immunization program.