Clinicopathological analysis of IgA nephropathy patients with minimal proteinuria

Objective:To study the clinicopathological features of IgA nephrology(IgAN)patients with minimal proteinuria and investigate the risk factors associated with renal injury.Methods:The clinical,laboratory and pathological manifestations of all IgAN patients with minimal proteinuria were retrospectively analyzed and compared.Results:Of all the renal biopsy cases in the past five years,IgAN with minimal proteinuria consisted of 10.2%,359(87.1%)patients had normal renal function and 53(12.9%)patients had abnormal renal function.Higher hypertension,higher level of serum uric acid and more proteinuria were found in cases with renal insufficiency(P0.01,P0.05)compared with those of normal renal function.The glomerular,tubulointerstitial and vascular damage index were more higher in patients with abnormal renal function.Conclusion:Severe renal histological injury and decrease of renal function may be seen in some IgAN patients with minimal proteinuria.Proteinuria,hypertension and serum uric acid effect the prognosis of these patients.Renal biopsy is important in these patients.