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HPLC-ELSD Fingerprints of genuine Semen Ziziphi Spinosae from Hebei Province

Rui Feng

Open publisher page 1 citations

Abstract

Objective To establish a fingerprint analysis method for identification and effective quality control of genuine Semen Ziziphi Spinosae from Hebei Province.Methods The HPLC-ELSD fingerprints for 21 batches of Semen Ziziphi Spinosae from different habitats were obtained by Waters 1525 HPLC instruments.The HPLC separation was performed on a C18 analytical column gradient elution with a mixture consisting of acetonitrile and water at a flow rate of 1.0 mL/min by ELSD detector.The temperature of column was 35 ℃.Results The mutual model of HPLC-ELSD fingerprints was set up and the similarities to the crude drugs from different habitats were compared.Conclusion It is simple and quick to identify Semen Ziziphi Spinosae from different sources with the above-mentioned method which can be used as a quality control item for Semen Ziziphi Spinosae.

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Objective To establish a fingerprint analysis method for identification and effective quality control of genuine Semen Ziziphi Spinosae from Hebei Province.Methods The HPLC-ELSD fingerprints for 21 batches of Semen Ziziphi Spinosae from different habitats were obtained by Waters 1525 HPLC instruments.The HPLC separation was performed on a C18 analytical column gradient elution with a mixture consisting of acetonitrile and water at a flow rate of 1.0 mL/min by ELSD detector.The temperature of column was 35 ℃.Results The mutual model of HPLC-ELSD fingerprints was set up and the similarities to the crude drugs from different habitats were compared.Conclusion It is simple and quick to identify Semen Ziziphi Spinosae from different sources with the above-mentioned method which can be used as a quality control item for Semen Ziziphi Spinosae.

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Available abstract

Objective To establish a fingerprint analysis method for identification and effective quality control of genuine Semen Ziziphi Spinosae from Hebei Province.Methods The HPLC-ELSD fingerprints for 21 batches of Semen Ziziphi Spinosae from different habitats were obtained by Waters 1525 HPLC instruments.The HPLC separation was performed on a C18 analytical column gradient elution with a mixture consisting of acetonitrile and water at a flow rate of 1.0 mL/min by ELSD detector.The temperature of column was 35 ℃.Results The mutual model of HPLC-ELSD fingerprints was set up and the similarities to the crude drugs from different habitats were compared.Conclusion It is simple and quick to identify Semen Ziziphi Spinosae from different sources with the above-mentioned method which can be used as a quality control item for Semen Ziziphi Spinosae.

Key concepts: Chromatography detector, Semen, High-performance liquid chromatography, Gradient elution, Chromatography, Fingerprint (computing), Chemistry, Biology

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