The relationship between transaminase anomaly and prognosis in patients with severe brain injury

Objective To investigate the relationship between transaminase anomaly and prognosis. in severe brain injury. Methods Total 117 cases with severe traumatic brain injury from January 2010 to June 2012 were admitted and detect the blood level of the alanine transarninase (ALT) and glutamic-oxal(o)acetic transaminase (AST). Transaminase anomaly included ALT 50 U/L and (or) AST 50 U/L. According to the test results, they were divided into transaminase anomaly group and normal group. The level of ALT, AST and different GOS prognostic score were compared in both groups. Results The favorable prognosis rate in transaminase anomaly group was lower than that of the normal group (χ2=4.71, P0.05), with the mortality higher than that of normal group (χ2=5.42, P0.05). The level of ALT and AST in transaminase anomaly group was significantly related with GOS prognosis, and the higher transaminase level is, the worse the prognosis. Conclusion Transaminase elevated level are often contributed to severe traumatic brain injury. The careful monitoring and protection of the liver function have a favorable effect on improvement of the prognosis of brain injury patients.