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1999•Chinese Journal of PharmaceuticalsRequires access

EFFECT OF DOMESTIC RECOMBINANT HUMAN GRANULOCYTE COLONY STIMULATING FACTOR (rhG CSF) ON HEMATOPOIETIC SYSTEM

Xin Li

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Abstract

The test was designed to study the effect of rhG CSF on hematopoietic system in vivo and in vitro . It was found that an appropriate rhG CSF treatment for 10 days after a 5.6 Gy radiation exposure of mice and a 50 mg/kg(iv) cyclophosphomide adminstration of monkeys to enhance hematopoietic reconstitution, leading to an earlier recovery. Treated mice and monkeys demonstrated effective granulocyte levels in the peripheral blood. Also, rhG CSF stimulated the formation of granulocytic colonies in mice and human semiso lid cultures in a dose related manner. The domestic rhG CSF is comparable to the imported Neupogen.

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What this paper is about

The test was designed to study the effect of rhG CSF on hematopoietic system in vivo and in vitro . It was found that an appropriate rhG CSF treatment for 10 days after a 5.6 Gy radiation exposure of mice and a 50 mg/kg(iv) cyclophosphomide adminstration of monkeys to enhance hematopoietic reconstitution, leading to an earlier recovery. Treated mice and monkeys demonstrated effective granulocyte levels in the peripheral blood. Also, rhG CSF stimulated the formation of granulocytic colonies in mice and human semiso lid cultures in a dose related manner. The domestic rhG CSF is comparable to the imported Neupogen.

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Available abstract

The test was designed to study the effect of rhG CSF on hematopoietic system in vivo and in vitro . It was found that an appropriate rhG CSF treatment for 10 days after a 5.6 Gy radiation exposure of mice and a 50 mg/kg(iv) cyclophosphomide adminstration of monkeys to enhance hematopoietic reconstitution, leading to an earlier recovery. Treated mice and monkeys demonstrated effective granulocyte levels in the peripheral blood. Also, rhG CSF stimulated the formation of granulocytic colonies in mice and human semiso lid cultures in a dose related manner. The domestic rhG CSF is comparable to the imported Neupogen.

Key concepts: Haematopoiesis, Granulocyte colony-stimulating factor, Granulocyte, In vivo, In vitro, Hematopoietic growth factor, Recombinant DNA, Peripheral blood

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EFFECT OF DOMESTIC RECOMBINANT HUMAN GRANULOCYTE COLONY STIMULATING FACTOR (rhG CSF) ON HEMATOPOIETIC SYSTEM — Research Paper | ScholarLens