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Resistance Analysis and CTX-M Genotype of Klebsiella pneumoniae and Escherichia coli Producing ESBLs in Yinchuan

Jun Du

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Abstract

To study the genotype distribution of CTX-M genotype in extended-spectrum β-lactamases(ESBLs)-producing Klebsiella pneumoniae and Escherichia coli strains isolated from four hospitals in Yinchuan of Ningxia.The minimal inhibitory concentration(MIC) of 45 E.coli and K.pneumonia to 10 antibacterial agents was detected by the NCCLS broth microdilution method(BMD).PCR,gene cloning and DNA sequencing were carried out for ESBLs genotyping.The sensitive rate of the 45 bacteria to meropenem was 100%.The resistant rate of ESBLs-producing isolates against AMP,KAN,NET,SMX,CTX,CRO,CF was above 64%.41 strains produced CTX-M genotype ESBLs,most of which was CTX-M-14 type,next was CTX-M-28.

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What this paper is about

To study the genotype distribution of CTX-M genotype in extended-spectrum β-lactamases(ESBLs)-producing Klebsiella pneumoniae and Escherichia coli strains isolated from four hospitals in Yinchuan of Ningxia.The minimal inhibitory concentration(MIC) of 45 E.coli and K.pneumonia to 10 antibacterial agents was detected by the NCCLS broth microdilution method(BMD).PCR,gene cloning and DNA sequencing were carried out for ESBLs genotyping.The sensitive rate of the 45 bacteria to meropenem was 100%.The resistant rate of ESBLs-producing isolates against AMP,KAN,NET,SMX,CTX,CRO,CF was above 64%.41 strains produced CTX-M genotype ESBLs,most of which was CTX-M-14 type,next was CTX-M-28.

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Available abstract

To study the genotype distribution of CTX-M genotype in extended-spectrum β-lactamases(ESBLs)-producing Klebsiella pneumoniae and Escherichia coli strains isolated from four hospitals in Yinchuan of Ningxia.The minimal inhibitory concentration(MIC) of 45 E.coli and K.pneumonia to 10 antibacterial agents was detected by the NCCLS broth microdilution method(BMD).PCR,gene cloning and DNA sequencing were carried out for ESBLs genotyping.The sensitive rate of the 45 bacteria to meropenem was 100%.The resistant rate of ESBLs-producing isolates against AMP,KAN,NET,SMX,CTX,CRO,CF was above 64%.41 strains produced CTX-M genotype ESBLs,most of which was CTX-M-14 type,next was CTX-M-28.

Key concepts: Klebsiella pneumoniae, Broth microdilution, Microbiology, Genotype, Klebsiella pneumonia, Meropenem, Escherichia coli, Biology

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Resistance Analysis and CTX-M Genotype of Klebsiella pneumoniae and Escherichia coli Producing ESBLs in Yinchuan — Research Paper | ScholarLens