Preparation of Cellulose Tris(3,5-Dimethylphenylcarbamate) Stationary Phase and Separation of Different Kinds of Chiral Compounds in GC

Cellulose tris(3,5-Dimethylphenylcarbamate) stationary phase has been synthesized and prepared for the chiral column of GC.The column efficiency,polarity and selectivity are studied,and the retention mechanism is discuss.Results showed that the polarity of the column is moderate,the column performance is up to 1895 plates/m,and the capacity factor is 1.52.Chiarl compounds,such as alcohols,amine,ketone,ether,ester,amino acides,separate well on the column.It can also be found that six compounds(Roseoxide,Dihydrocarvylacetate,N-Benzyl-1-phenylethylamine,Fenchone,Leucine and Isoleucine) are completely attained with better separation.Among the 25 recemates,20 chiral compounds could be separated on the column.So,the cellulose tris(3,5-Dimethylphenylcarbamate) stationary phase has the recognition for chirality and can be used as chiral stationary phase in GC.