The curative effect of Sijunzhi Decoction on patients with diarrhea-predominant irritable bowel syndrome and to the influence of the serum IL-1β,IL-8

Objective: To investigate the clinical curative effect and possible function mechanism of compound Chinese herbal medicine Sijunzhi Decoction on patients with diarrhea-prele bowel syndrome.Methods: Patients with diarrhea-predominant irritable bowel matches diarrhea type bowel were treated by Sijunzhi Decoction.After 4 weeks,the integral calculus of symptom and the level of intrerleukin 1β,8(IL-1β,IL-8) in serum were meassured.Results: Sijunzhi Decoction could obvious lower the integral calculus of symptom on patients with diarrhea-predominant irritable bowel syndrome,and lower the level of the IL-1β,IL-8 in serum.Conclusion: Sijunzhi Decoction can improve the integral calculus of symptom on patients with diarrhea-predominant irritable bowel syndrome,its function may has something to do with lowering the levels of IL-1β,IL-8.