Efficacy and safety of Candesartan cilexetil in treatment of patients with mild and moderate essential hypertension

Objective To evaluate efficacy and safety of Candesartan cilexetil in treatment of patients withmild and moderate essential hypertension.Method 48 patients with mild and moderate essential hypertensionwere randomized and double-blind divided into Candesartan group(N=24) and Losartan group(N=24) after theyhad finished the induction treatment.If the blood pressure was still over standard,the doseage of drugs usedwere doubled from the 5th week till the 8th .Blood pressure,heart rate and side effects were investigated every2 weeks.Before and after trial laboratory test (liver and renal function,blood and urine routine) were performed.Results The antihypertensive efficacy rate of the two drugs were 100%.The systolic blood pressure(SBP)and(Continued to page 62)diastolic blood pressure(DBP)in two groups decreased significantly after the study being taken for two weeks.And from then on,the SBP and DBP in two groups continued decline.Compared with before the trial the SBPand DBP decreased 20.3mmHg and 16.8mmHg,respectively, in Candesartan group,and in Losartan group theSBP and DBP decreased 16.4mmHg and 16.1mmHg,separately,on the end of this trial. Except one patientappearing moderate headache,one appearing mild chest discomfort and abdominal distension,the others hadno discomfortable feeling.All laboratory tests were normal.Conclusion Candesartan cilexetil like Losartan maybe used in the antihypertension treatment of patients with mild and moderate essential hypertension effec-tively and safely.[