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Advances in Tumor Angiogenesis Inhibitor

Hao Zhu

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Abstract

Both tumor growth and invasion of malignant tumors are dependent on angiogenesis. Tumor angiogenesis is controlled by various regulative factors, such as vascular endothelial growth factor (VEGF), angiogenin, fibroblast growth factor (FGF), angiostatin, endostatin , thrombospondin(TSP 1), etc. Anti angiogenic agents represent a new approach to anticancer therapy. In this article, the mechanisms of angiogenesis were introduced briefly and the advances in tumor angiogenesis inhibitor were emphasized especially.

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What this paper is about

Both tumor growth and invasion of malignant tumors are dependent on angiogenesis. Tumor angiogenesis is controlled by various regulative factors, such as vascular endothelial growth factor (VEGF), angiogenin, fibroblast growth factor (FGF), angiostatin, endostatin , thrombospondin(TSP 1), etc. Anti angiogenic agents represent a new approach to anticancer therapy. In this article, the mechanisms of angiogenesis were introduced briefly and the advances in tumor angiogenesis inhibitor were emphasized especially.

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Available abstract

Both tumor growth and invasion of malignant tumors are dependent on angiogenesis. Tumor angiogenesis is controlled by various regulative factors, such as vascular endothelial growth factor (VEGF), angiogenin, fibroblast growth factor (FGF), angiostatin, endostatin , thrombospondin(TSP 1), etc. Anti angiogenic agents represent a new approach to anticancer therapy. In this article, the mechanisms of angiogenesis were introduced briefly and the advances in tumor angiogenesis inhibitor were emphasized especially.

Key concepts: Angiostatin, Angiogenin, Angiogenesis, Endostatin, Fibroblast growth factor, Angiogenesis inhibitor, Cancer research, Thrombospondin 1

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