MiR-155 expression in gastric cancer tissues and its clinical significance

Objective: To investigate the miR-155 expression in gastric cancer tissues and its clinical relevance. Methods: The surgical specimens of 52 cases of stomach cancer and their adjacent normal tissues were collected.The miR-155 expression level in gastric cancer and adjacent normal tissues were determined by real-time reverse transcriptase-polymerase chain reaction(RT-PCR) technique,and the relations of miR-155 expression with the clinicopathologic factors of gastric cancer were analyzed. Results: The RT-PCR results showed that the miR-155 expression value in gastric cancer tissues(0.84±2.27) was significantly higher than that in their paired adjacent normal tissues(0.28±0.56)(P0.05).The miR-155 expression level was associated with the lymph node metastases in gastric cancer patients,the miR-155 expression in patients with the lymph node metastases was higher than that in those without lymph node metastases(P0.05).The miR-155 expression level was irrelevant to the sex,age,tumor size,depth of invasion,and all the differences between the groups on these factors had no statistical significance(all P0.05). Conclusion: miR-155 has high expression level in gastric cancer tissues,and it may be relevant to gastric cancer lymph node metastasis.