ScholarLens Back to search
2006•Zhongguo linchuang yaolixue yu zhiliaoxueRequires access

Investigation of bioequivalence of capsules and tablets of complex chlorzoxazone in healthy volunteers

HU Qi-sheng

Open publisher page 0 citations

Abstract

AIM: To investigate the bioequivalence between capsules and tablets of complex chlorzoxazone in healthy volunteers.METHODS:twenty volunteers were randomly divided into two groups(test and reference),ten in each,with crossover design.The concentration of complex chlorzoxazone was determined by HPLC and pharmacokinetic parameters were calculated with DAS(2.0) practical pharmacokinetics program.RESULTS:The relative bioavalibility of chlorzoxazone and acetaminophen in complex chlorzoxazone capsules were((109.1)±(30.9))% and((114.0)±(50.5))%,respectively.CONCLUSION: The statistical analysis showed that the test and reference preparation were bioequivalent.

About this research paper

What this paper is about

AIM: To investigate the bioequivalence between capsules and tablets of complex chlorzoxazone in healthy volunteers.METHODS:twenty volunteers were randomly divided into two groups(test and reference),ten in each,with crossover design.The concentration of complex chlorzoxazone was determined by HPLC and pharmacokinetic parameters were calculated with DAS(2.0) practical pharmacokinetics program.RESULTS:The relative bioavalibility of chlorzoxazone and acetaminophen in complex chlorzoxazone capsules were((109.1)±(30.9))% and((114.0)±(50.5))%,respectively.CONCLUSION: The statistical analysis showed that the test and reference preparation were bioequivalent.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

AIM: To investigate the bioequivalence between capsules and tablets of complex chlorzoxazone in healthy volunteers.METHODS:twenty volunteers were randomly divided into two groups(test and reference),ten in each,with crossover design.The concentration of complex chlorzoxazone was determined by HPLC and pharmacokinetic parameters were calculated with DAS(2.0) practical pharmacokinetics program.RESULTS:The relative bioavalibility of chlorzoxazone and acetaminophen in complex chlorzoxazone capsules were((109.1)±(30.9))% and((114.0)±(50.5))%,respectively.CONCLUSION: The statistical analysis showed that the test and reference preparation were bioequivalent.

Key concepts: Chlorzoxazone, Bioequivalence, Pharmacokinetics, Pharmacology, Crossover study, Chemistry, Acetaminophen, Medicine

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Investigation of bioequivalence of capsules and tablets of complex chlorzoxazone in healthy volunteers — Research Paper | ScholarLens