Clinical effects of body γ-knife in patients with hepatic hilar carcinoma

Objective:To investigate the effect of stereotactic body radiotherapy(SBRT) in treatment of hepatic hilar tumors.Methods: From October 2006 to June 2010,63 cases of hepatic hilar tumors inoperable tumor were treated by SBRT,dose fractionation 3-6Gy,6-13 times irradiation,total dose(40-60)Gy,(2-5) times/week.After 1,3 month to evaluate therapeutic efficiency and 1 year,2 year survival rate.Results: After 1 month of treatment CR 15(23.8%),PR 34(54.0%),SD 11(17.5%),PD 3(4.8%),the total efficiency was 78.8%.Total bilirubin and direct bilirubin decreased to normal after treatment in 36(36/48,75%),efficiency of portal vein tumor thrombus was 40.9%.6 patients died within 3 months,failed to efficacy evaluation.After 1 month of treatment,CR 22(34.9%),PR 32(50.8%),SD 3(4.8%),the total effective rate was 85.7%(54/63).Total bilirubin and direct bilirubin were converted to normal in 40 cases(83.3%),five cases were close to normal.The effective rate of portal vein tumor thrombus was 63.6%.The effective rate of tumor diameter ≤5cm was CR 72.2%(13/18),CR + PR 94.4%(17/18),tumor diameter 5cm CR 20%(9/45),CR + PR 82.2%(37/45).1-year survival rate was 79.4%(50/63),2-year survival rate was 42.9%(27/63).Conclusion: SBRT is a safe and effective treatment to hepatic hilar tumors.