2006•Zhongguo mianyixue zazhiRequires access

Jurkat cell apoptosis induced by anti-human DR5 monoclonal antibody (mDRA-6)

Shu Li

Abstract

Objective: To observe apoptotic effect of anti-human DR5 (death receptor 5 of TRAIL) monoclonal antibody (mDRA-6) on Jurkat cell. Methods:Morphologic changes of Jurkat cells were observed by a microscope. Apoptotic effects of mDRA-6 on Jurkat cells were detected by MTT and FCM analyse. Results:Chromatic margination,budding and apoptotic bodies were observed in Jurkat cells treated by mDRA-6; Viability of Jurkat cells is decreased and apoptosis of Jurkat cells is increased obviously. Conclusion: Apoptosis of Jurkat cell can be induced by anti-human DR5 monoclonal antibody (mDRA-6).

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Key concepts: Jurkat cells, Apoptosis, Chemistry, Monoclonal antibody, Cell biology, Antibody, T cell, Biology