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2009•Journal of OncologyRequires access

A Clinical Study of Disseminated Candida Tropicalis Fungemia in Patients with Acute Leukemia

Qingqi Chen

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Abstract

[Purpose] To improve the recognition of clinical characteristics of disseminated Candida tropicalis fungemia in patients with acute leukemia(AL). [Methods] Clinical manifestations, diagnosis, treatment and prognosis were retrospectively investigated in 3 cases of AL patients with disseminated Candida tropicalis fungemia. [Results] Of 3 cases, persistent fever and thrush occured during the time of agranulocytosis, spherical-like or oval multiple low-level echoes were detected in liver under type-B ultrasonic. Candida tropicalis was found by hemoculture. The temperature recovered normal after amphotericin B and flucytosin (5-FC) treatment in 3 cases. [Conclusion] The diagnosis of disseminated Candida tropicalis fungemia needs to be combined with clinical manifestation, laboratory examination and imaging examination. Combined amphoteriein B and flucytosin (5-FC) treatment has a favorable response.

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What this paper is about

[Purpose] To improve the recognition of clinical characteristics of disseminated Candida tropicalis fungemia in patients with acute leukemia(AL). [Methods] Clinical manifestations, diagnosis, treatment and prognosis were retrospectively investigated in 3 cases of AL patients with disseminated Candida tropicalis fungemia. [Results] Of 3 cases, persistent fever and thrush occured during the time of agranulocytosis, spherical-like or oval multiple low-level echoes were detected in liver under type-B ultrasonic. Candida tropicalis was found by hemoculture. The temperature recovered normal after amphotericin B and flucytosin (5-FC) treatment in 3 cases. [Conclusion] The diagnosis of disseminated Candida tropicalis fungemia needs to be combined with clinical manifestation, laboratory examination and imaging examination. Combined amphoteriein B and flucytosin (5-FC) treatment has a favorable response.

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Available abstract

[Purpose] To improve the recognition of clinical characteristics of disseminated Candida tropicalis fungemia in patients with acute leukemia(AL). [Methods] Clinical manifestations, diagnosis, treatment and prognosis were retrospectively investigated in 3 cases of AL patients with disseminated Candida tropicalis fungemia. [Results] Of 3 cases, persistent fever and thrush occured during the time of agranulocytosis, spherical-like or oval multiple low-level echoes were detected in liver under type-B ultrasonic. Candida tropicalis was found by hemoculture. The temperature recovered normal after amphotericin B and flucytosin (5-FC) treatment in 3 cases. [Conclusion] The diagnosis of disseminated Candida tropicalis fungemia needs to be combined with clinical manifestation, laboratory examination and imaging examination. Combined amphoteriein B and flucytosin (5-FC) treatment has a favorable response.

Key concepts: Candida tropicalis, Fungemia, Medicine, Amphotericin B, Acute leukemia, Leukemia, Internal medicine, Antifungal

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