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Detection of AmpC and extended spectrum β-lactamases in Escherichia coli and Klebslella pneumoniae and analysis of resistance

Wei Ge

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Abstract

Objective:To investigate the production and resistance of AmpC β-lactamases and extended spectrum β-lactamases(ESBLs) in Escherichia coli and Klebslella pneumoniae in our hospital.Methods:A modified three diamensions extract test was used to detect AmpC and ESBLs were detected by the disk diffusion method recommended by CLSI/NCCLS.Results:The producing rate of AmpC,ESBLs and AmpC+ESBLs in Escherichia coli and Klebslella pneumoniae was 9.3%,4%,28%,12%,14.7% and 0,respectively,and their resistance rates of enzyme-producing strains were lower than 15% against imipenen and higher than 50% against other antibiotics.Conclusion:The resistance of enzyme-producing strains was very severe.Therefore,the antibiotics should be used rationally to prevent spread of drug resistant bacteria.

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What this paper is about

Objective:To investigate the production and resistance of AmpC β-lactamases and extended spectrum β-lactamases(ESBLs) in Escherichia coli and Klebslella pneumoniae in our hospital.Methods:A modified three diamensions extract test was used to detect AmpC and ESBLs were detected by the disk diffusion method recommended by CLSI/NCCLS.Results:The producing rate of AmpC,ESBLs and AmpC+ESBLs in Escherichia coli and Klebslella pneumoniae was 9.3%,4%,28%,12%,14.7% and 0,respectively,and their resistance rates of enzyme-producing strains were lower than 15% against imipenen and higher than 50% against other antibiotics.Conclusion:The resistance of enzyme-producing strains was very severe.Therefore,the antibiotics should be used rationally to prevent spread of drug resistant bacteria.

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Available abstract

Objective:To investigate the production and resistance of AmpC β-lactamases and extended spectrum β-lactamases(ESBLs) in Escherichia coli and Klebslella pneumoniae in our hospital.Methods:A modified three diamensions extract test was used to detect AmpC and ESBLs were detected by the disk diffusion method recommended by CLSI/NCCLS.Results:The producing rate of AmpC,ESBLs and AmpC+ESBLs in Escherichia coli and Klebslella pneumoniae was 9.3%,4%,28%,12%,14.7% and 0,respectively,and their resistance rates of enzyme-producing strains were lower than 15% against imipenen and higher than 50% against other antibiotics.Conclusion:The resistance of enzyme-producing strains was very severe.Therefore,the antibiotics should be used rationally to prevent spread of drug resistant bacteria.

Key concepts: Escherichia coli, Microbiology, Antibiotics, Antibiotic resistance, Klebsiella pneumoniae, Drug resistance, Bacteria, Biology

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