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Syntheses of [2-~(15)N] tryptamine and [2-~(15)N] perlolyrine

Tang Ganghu

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Abstract

15Nb-tryptamine was synthesized starting from [a -15N] glycine via 7 steps. Theyield of 15Nb-tryptamine from [a -15N] glycine was 45%. [2-15N] perlolyrine wassynthesized from 15Nb-tryptamine via 3 steps, the yield of [2-15N] perlolyrine from15Nb-tryptamine was 22.2%. The 15N abundance of [2-15N] perlolyrine was morethan 90%. The synthetic showed that the synthetic compounds were suitable for thestuding of drug metabolism.

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What this paper is about

15Nb-tryptamine was synthesized starting from [a -15N] glycine via 7 steps. Theyield of 15Nb-tryptamine from [a -15N] glycine was 45%. [2-15N] perlolyrine wassynthesized from 15Nb-tryptamine via 3 steps, the yield of [2-15N] perlolyrine from15Nb-tryptamine was 22.2%. The 15N abundance of [2-15N] perlolyrine was morethan 90%. The synthetic showed that the synthetic compounds were suitable for thestuding of drug metabolism.

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Available abstract

15Nb-tryptamine was synthesized starting from [a -15N] glycine via 7 steps. Theyield of 15Nb-tryptamine from [a -15N] glycine was 45%. [2-15N] perlolyrine wassynthesized from 15Nb-tryptamine via 3 steps, the yield of [2-15N] perlolyrine from15Nb-tryptamine was 22.2%. The 15N abundance of [2-15N] perlolyrine was morethan 90%. The synthetic showed that the synthetic compounds were suitable for thestuding of drug metabolism.

Key concepts: Tryptamine, Yield (engineering), Glycine, Chemistry, Stereochemistry, Biochemistry, Amino acid, Materials science

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