Early diagnostic values of the joint measurements of serum cystatinC,β_2-microglobulin and urinary mAlb in patients with diabetic nephropathy

Objective To explore the early diagnostic values of the joint measurements of serum cystatinC(Cys C),β2-microglobulin(β2-MG) and urinary microalbumin(UmALB) in patients with diabetic nephropathy.Methods The levers of Cys C,β2-MG,urea,crtinine(Cr) and UmALB in 95 patients with type 2 diabetes mellitus,including urine protein negative group(58 cases),the urine protein positive group(37 cases),and 50 healthy controls were measured.Results Serun Cys C,β2-MG and UmALB levels in the two groups of diabetic nephropathy patients were significantly higher than those in the healthy controls(P0.01).However,serum urea and Cr levels in the urine protein negative group and the healthy controls were no with significant differences(P0.05).Serum urea and Cr levels in the urine protein positive group were significantly higher than those in the urine protein negative group and healthy controls(P0.01).Positive rate of the two groups were compared,the positive rate of serum Cys C,β2-MG and UmALB were higher than the positive rate of serum urea and Cr in the urine protein negative group,and the differences were statistically significant(P0.01).However,the positive rate of serum Cys C,β2-MG and UmALB and the positive rate of serum urea and Cr were no with significant differences in the urine protein positive group(P0.05).The sensitivity and accuracy of the joint measurement of serum Cys C,β2-MG and UmALB levels were obviously better than those of a single measurement(P0.01).Conclusion Serum Cys C,β2-MG and UmALB concentrations in patients with diabetic nephropathy could significantly increased,and the early clinical diagnosis of the three combined measurements in patients with diabetic nephropathy have important significance.