The early diagnostic value of oral acetazolamide load test SPECT rCBF imaging in patients with TIA

Objective To assess the diagnostic value of acetazolamide(ACZ) vasoactive test using regional cerebral blood flow (rCBF) SPECT imaging in patients with TIA.Methods SPECT imaging was performed before and after oral ACZ vasoactive test combining with visual and semiquantitative analysis of tomogram.Blood gas analysis was also done before and after ACZ test.Results After ACZ test in normal group, 99m TC ECD was distributed symmetrically on corresponding parts of the brain and CBF was generally increased.The value of blood pH was decreased and blood PCO 2 was increased in TIA group after ACZ test.The positive rate of local hypoperfusion lesion on SPECT imaging increased from 5/6 to 6/6 in symptomatic TIA patients and from 60% to 92% in asymptomatic patients.The total positive rate was 93% after ACZ test.Conclutions The method of oral ACZ vasoactive test using SPECT imaging was simple,reliable and has early diagnostic value in patients with TIA.