Treatment of Acute Bacterial Infections with Amoxicillin/Sulbactam Sodium

Objective:To study the clinical effect and security of amoxicillin/sulbactam of China-produce in treating acute bacterial infections. Methods:By using the design of randomized single-blind controlled clinical trial, 41 patients were divided into two groups: trail group 21 and control group 20. The trial group was give, amoxillin/sulbactam 4.5-9.0g·d -1 , The control group was given ampicillin/sulbactam 4.5-12.0 g·d -1 , The drug injections being divided into 2 to 3 portions given by intravenous drip for both groups. Results:In the trail and the control groups, the recover rates were 71.4% and 75.0% respectively, the effectiveness rates were 95.2% and 95.0%, the positive bacterium rates were 80.9% and 90.0%, the rates of produced-enzyme were 76.5% and 66.7%, the rates of bacterium-clearance were 94.1% and 94.4%, and the incidences of adverse reaction were 9.5% and 15.0%. There was no significant difference about these parameters between the two groups ( P 0.05). Conclusion:Amoxicillin/sulbactam sodium for injection has a wide antibacterial spectrum, strong antibacterial activity, obvious curative effect and little adverse reaction.