Advances in studies on ATP-binding cassette transporter-mediated multidrug resistance in liver cancer

The failure of chemotherapy in liver cancer treatment often occurs as a result of multidrug resistance(MDR) mediated by ATP-binding cassette(ABC) transporters and the development of more effective therapies depends on identifying the mechanisms of intrinsic or acquired MDR.Strategies focused on ABC transporters to overcome MDR have a lot of benefits on the chemotherapy of liver cancer.Furthermore,considerable evidence suggests that the ABC transporters play a fundamental role in tumor biology beyond the efflux of cytotoxic drugs,which indicates a new way of study on cancer therapy.