Animal models and pathological changes in gastroesophageal reflux

Objective To investigate the factors leading to gastroesophageal reflux by animal models.Methods 40 newborn pigs were divided into 5 groups, each group including 8 animals. Of them, 4 groups were treated with different operation to induce gastroesophageal reflux, the other one was control group. Gastroesophageal reflux was determined by barium meal examination, esophageal manometry and continuous esophageal pH monitoring. Plasma levels of motilin and neurotensin were determined by radioimmunoassay technique.Results Gastroesophageal reflux was due to compositive factors. Relaxed peristalsis and delayed gastric emptying may be important pathogenic factors in gastroesophageal reflux. Conclusions The mechanism of preventing gastroesophageal reflux involves compositive factors and coordination between pylorus duodenum and esophageal clearance movement plays a major role.