Recent Advances of Aromatase Inhibitor Letrozole

Letrozole is a novel potent nonsteroidal aromatase inhibitor,which has been shown to be useful as first-line therapy in postmenopausal women with advanced breast cancer(ABC).It was well tolerated and produced potent,selective and long-lasting inhibition of aromatase.Letrozole is an effective and safe agent for treatment of ABC.The advances in the research of the synthesis and clinical studies of Letrozole were reviewed in this paper.