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2003•Acta Academiae Medicinae JiangxiRequires access

Clinical Study of Fluoxetine and Clomipramine in the Treatment of Obsessive-Compulsive Disorder

Zou Sheng-jun

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Abstract

Objective To investigate the efficacy and the side effects of fluoxetine in the treatmeat of obsessive-compulsive disorder(OCD).Methods Sixty patients who met the CCMD-3 for OCD were involved in this study.Fluoxetine efficacy in treatment of OCD were assessed with Y-BOCS and the side effects of fluoxetine were evaluated with Treatment Emergent Symptom Scale(TESS)compared with clomipramine.Results The therapeutic efficacy in fluoxetine group was similar to that in clomipramine(P0.05).However,the side effects of fluoxetine were lighter than that of clomipramine.Conclusion The results indicate that both fluoxetine and clomipramine is effective in the treatment of OCD,but fluoxetine shows more advantage for its convenient administration and low daily dosage and its side effects were lighter.

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What this paper is about

Objective To investigate the efficacy and the side effects of fluoxetine in the treatmeat of obsessive-compulsive disorder(OCD).Methods Sixty patients who met the CCMD-3 for OCD were involved in this study.Fluoxetine efficacy in treatment of OCD were assessed with Y-BOCS and the side effects of fluoxetine were evaluated with Treatment Emergent Symptom Scale(TESS)compared with clomipramine.Results The therapeutic efficacy in fluoxetine group was similar to that in clomipramine(P0.05).However,the side effects of fluoxetine were lighter than that of clomipramine.Conclusion The results indicate that both fluoxetine and clomipramine is effective in the treatment of OCD,but fluoxetine shows more advantage for its convenient administration and low daily dosage and its side effects were lighter.

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Available abstract

Objective To investigate the efficacy and the side effects of fluoxetine in the treatmeat of obsessive-compulsive disorder(OCD).Methods Sixty patients who met the CCMD-3 for OCD were involved in this study.Fluoxetine efficacy in treatment of OCD were assessed with Y-BOCS and the side effects of fluoxetine were evaluated with Treatment Emergent Symptom Scale(TESS)compared with clomipramine.Results The therapeutic efficacy in fluoxetine group was similar to that in clomipramine(P0.05).However,the side effects of fluoxetine were lighter than that of clomipramine.Conclusion The results indicate that both fluoxetine and clomipramine is effective in the treatment of OCD,but fluoxetine shows more advantage for its convenient administration and low daily dosage and its side effects were lighter.

Key concepts: Clomipramine, Fluoxetine, Psychology, Obsessive compulsive, Side effect (computer science), Psychiatry, Therapeutic effect, Medicine

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