Clinicopathological significance of vascular endothelial growth factor C and its receptors in endometrial adenocarcinoma

Objective To investigate the expression of vascular endothelial growth factor-C(VEGF-C) and its receptor in endometrial adenocarcinoma tissue in pursuit of their role in tumor metastasis and other clinical significance.Methods 48 fresh endometrial adenocarcinoma tissue were examined by RT-PCR to detect the VEGF-C/KDR /Flt-4mRNA expression.Results There was a significant difference of VEGF-C/KDR /Flt-4mRNA expression between the tumor and the normal controls.And there was no significant relationship between VEGF-C mRNA,KDR mRNA or flt-4mRNA expression with the pathological types and clinical stage of invasive carcinoma of cervix.But the expression was significant association with the grade of tumor pathology,lymph node metastasis,tumor size and the invasion of deep muscular layer(P0.05).Conclusion The results suggest that the VEGF-C may play an important role in the lymph node metastasis and it could be a useful biological marker to foresee the lymph node metastasis and prognosis for cervical cancer.