Preparation of Molecularly Imprinted Nanoparticles for Erythromycin and Their Adsorption Characteristics

Uniform molecularly imprinted polymer (MIP) nanoparticles for erythromycin (EM) were prepared by precipitation polymerization using EM as template molecule, methacrylic acid (MAA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as cross-linker. The synthesis conditions of MIP nanoparticles were optimized and the optimum molar ratio of template molecule to functional monomer was obtained as 1:3. The MIP nanoparticles were characterized. Moreover, the actual maximum apparent adsorption capacity of MIP nanoparticles obtained from the binding experiments was 202.12 mg/g, the adsorption kinetics of MIP nanoparticles showed that the adsorption of MIP nanoparticles in adsorption solution would be equilibrium after 200 min. The MIP nanoparticles for EM possessed highly selective adsorption capacity.