An Analysis of the Clinical Parameters and Correlative Prognostic Factors for the 123 Cases with Pancreatic Cancer

[Purpose] To investigate potential factors related to survival in patients with pancreatic cancer.[Methods] One hundred and twenty-three cases with pancreatic cancer were analyzed retrospectively to study factors related to survival by Log-Rank and Cox multiplicity analysis.[Results] The median time to progress (TTP) and overall survival (OS) was 7.0 months and 11.6 months respectively.Stratified analysis showed that the median TTP(13 months) and median OS(24.3 months) of patients with stage Ⅰ and Ⅱ were longer than that of patients with stage Ⅲ and Ⅳ,and similarly,those with stage Ⅲ (median TTP:5 months;median OS:10.1 months) were better than those with stage Ⅳ (median TTP:2.5 months;median OS:3.9 months)(P0.001).The median TTP and OS in patients who received radical surgery were 11.3 months and 15.6 months respectively,were longer than those of non-excisional patients(including both shunt operation and paracentesis)(P0.01),but between palliative shunt operation and diagnostic paracentesis only,there were no statistical significance(median TTP:5 months vs.4.8 months;median OS:10.1 months vs.7.8 months).The median TTP and OS in patients with post-operation adjuvant therapy were longer than those in patients without (median TTP:12.8 months vs.4.6 months;median OS:16.9 months vs.8.7 months)(P0.01).[Conclusion] Cancer stage,surgical modality and adjuvant therapy are important prognostic factors of pancreatic cancer.