The expression of VEGF and NET-1 protein in astrocytic tumors and their relevance with tumor angiogenesis

Objective To observe the expression and clinical significance of NET-1 protein,vascular endothelial growth factor(VEGF) in human astrocytic tumors and study their relevance with tumor angiogenesis and grade.Methods The expression of NET-1 and VEGF in astrocytic tumors was detected with immunohistochemical techniques,and the correlation between the expression of NET-1 and VEGF and tumor microvascular density(MVD) was analized by univariate analysis and spearman.Results The expression rate of NET-1 and VEGF in cerebral astrocytoma was 63.33%(38/60) and 58.33%(35/60) respectively and the difference between low-grade and high-grade neoplasia group was significant(all P0.05).The averages of MVD in the groups in which NET-1 and VEGF showed different expression intensity showed the significant differences statistically(P0.05).Conclusion The expression of both NET-1 and VEGF in high-grade cerebral astrocytoma is significantly higher than that in the low-grade,and has significant correlation with MVD.Therefore,the expression of NET-1 and VEGF has potential diagnostic value for the grading of cerebral astrocytoma.