An Initial Study on Cyclooxygenase-2 Esophagus in Esophagus Cancer

Objective To research the cyclooxygenase-2 protein expression and its effect in the esophagus cancer. Methods 34 cases of esophagus cancer specimens were examined the expression of COX-2 by immunohistochemical method and Western blotting method. Results The significant positive rates of COX-2 expression in esophagus cancer was 71%,but the significant positive expression in the adenocarcinoma and squamous carcinoma is not significant difference.Statistics test showed that the age,gender,tissue differentiation,clinical stage(TNM) and node metastasis did not affect the COX-2 significant expression in esophagus cancer. Conclusion The COX-2 protein significant positive expression may be closely associated with the occurrence,form and development of the esophagus cancer.