Influence on continuously local intrabiliary duct pressure level on biliary duct wall in dogs

Objective To investigate the influence on the size of local intrabiliary duct pressure and continuence for biliary duct wall in dogs. Methods An inlaid bile duct dilator (IBDD) was designed and made by ourself. The relationship between dilated intra-balloon pressure, injcted water volume and diameter of sac were detected in vitro. 21 mongrel dogs were randomly divided into 5 groups. The group A was false operative group and bile duct dilator was placed only in common bile duct. 0.1 and 0.2 ml volume of water were injected to dilated intra-balloon in group B and C respectively (balloon pressure was 0.24 and 0.58 kPa respecvively). After dilated common bile duct for 10 minutes, the balloon was evacuated and bile duct dilator was placed as biliary drainage. In the group D and E,0.1 and 0.2 ml volume of water were injeted to dilated intra-balloon respectively. After dilated common bile duct, the balloon was not evacuated and it was placed as biliary dranage. Each group was re-laparostomy after operation 7th day respectively. Value of serum total bilirubin, ALT and AST, and changes of diameter of bile duct (BD), bile duct wall and liver histology were observed in each group before and after dilatation. Results In comparing with group A, the BD was expanded after dilation in group C(P0.05=, BD was expanded obviously after dilation in group D(P0.01=,serum total bilirubin (TB), ALT and AST were increased after dilation in group E(P0.01=. There was no significant difference in histologic changes of biliary duct wall in group A and B. The biliary duct wall showed mucosal hyperemia and edema and partial mucosal exfoliation in group C. Diameter of bile duct was coarsened and bile duct wall was thickening in group D. Bile duct wall had partial necrosis and it was adhereent to the omentum or duodenum in group E. Conclusion The bidirectional interconversion relationship between the influence on size of local intra-biliary duct pressure and continuence for biliary duct wall in dogs. Normol biliary duct wall can bear local intra-biliary duct pressure in some degree within definite time and it cannot induce pathologic changes. A local suitable intra-biliary duct pressure can lead to dilatation of local bile duct and it's bile duct wall of upper stream. On the contrary, bile duct wall would cause destructive changes.