Analysis of immunophenotype of B lineage acute lymphoblastic leukemia in adult patients

Objective To investigate the immunophenotype of B cell acute lymphoblastic leukemia in adult patients.Methods Immunophenotyping was performed by flow cytometry in 145 adult patients with B cell acute lymphoblastic leukemia.Results The highest incidence of lymphoid associated antigens were CD19,HLA-DR and CD79a,followed by CD34,CD10 and CD20.B-ALL had a higher expression rate of myeloid antigens CD13,CD33 and CD15,CD117 and T antigens(CD7 and CD56) were rarely expressed.Subtype Ⅱ(CD10+/CD34+)was predominant in three age groups of adults.The LAIP was observed in 100.0% and 90.1% patients of subtype Ⅰ and subtype Ⅱ,respectively,whereas only 72.7% and 63.6% in subtype Ⅲ and subtype Ⅳ.There was no significant difference in incidence of LAIP between three age groups(P0.05).Conclusion The immunophenotype by flow cytometry is of great value in correct diagnosis and minimal residual disease detection of B cell acute lymphoblastic leukemia.