Advances in the Research of Cell Division Mode and Its Mechanisms

Cell mitoses fall into two categories: symmetric division and asymmetric division in terms of whether the cell-fate determinants are distributed to the two daughter cells equally or not.The regulations of cell division modes play a critical role in the cell proliferation and differentiation during embryogenesis.Many molecules participate in this procedure.The major function of Par complex, Crb complex and Scrib complex is to direct the asymmetric localization of cell-fate determinants such as Numb through their interaction with LgI and DIg, to establish cell polarity.However, Incuteable, Pins and G protein complex works-mainly on the control of spindle orientation.Through coordination of spindle orientation and asymmetric localization of cell-fate determinants in mitosis, they eventually lead to special mode of cell division.