Study of Mitoxantrone and FLAG Regimen in Treatment of Refractory and Relapsed Acute Myeloid Leukemia

Objective To evaluate the effect of fludarabine,Mitoxantrone and G-CSF regimen in treatment of refractory and relapsed acute myeloid leukemia.Methods 20 patients with refractory or relapsed acute myeloid leukemia(10 refractory AML patients,10 relapsed AML patients)were treated with the regimen.Results The rate of complete remission was 65%(13 /20),the rate of partial remission 10%(2/20),and the overall response rate 75.0%.Main toxicities were myelosupression and neutropenia,gastrointestinal side effects.Conclusion The regimen can be employed in treatment of the refractory or relapsed patients who were not responded to other regimen,and it is safe and effective.