Effects of Esmolol on Cardiovascular Response of Ketamine

Objective: To observe the clinical effects of esmolol on cardiovascular response of ketamine. Methods: 32 children with ASA status Ⅰ scheduled for selected surgery under ketamine general anesthesia were divided into two groups: control group and study group (n=16). Anesthesia was induced with bolus of ketamine 1mg/Kg and maintain with the ketmine infusion at the rate of 2.5mg/kg/h in all children. In study group, a bolus of esmolol 1mg/Kg was administrated intravenously before anesthesia induction, then the infusion of esmolol at the rate of 0.1mg/kg/min was maintained. And in control group, any esmolol was not administrated. The MAP and HR were monitored and recorded before the anesthesia induction(T0), at 2 min(T1) and 5min (T2)after the anesthesia induction, and at 5min after the beginning of surgery (T3). Results: At the measure points of T1, T2 and T3 after the ketamine administration, the HR and MAP in control group increased significantly compared with T0 (p0.05); the HR and MAP did not changed significantly in study group (p 0.05); When compared between the two groups, At the measure points of T1, T2 and T3, the HR and MAP in study group were lower than those in control group (p0.05). Conclusion: The administration of esmolol can effectively attenuate the cardiovascular response of ketamine, such as the increase of the blood pressure and the heart rate and keep the circulation of the children steady during ketamine adiministration.