Tclinical Significance of Serum TBA Determination in Patients with acute and Chronic Hepatitis

Objective To investigate the clinical application value of serum TBA concentration of serum TBA in 96 cas- es of healthy controls,117 cases of nonhepatosis and 188 cases of acute and chronic hepatitis was determined by cyclic en- zyme kinetic method.The 99% standard of x+s of controls was chosen to define reference high valus to evaluate Diagnostic efficiency.Results serum TBA level in healthy controls and in non-bepatosis was 5.34+3.74 umol/L and 5.06±2.87umol/L, there was no statistical difference(P0.06).Acute hepatitis level increased significantly to 34.51±29.28umol/L(P0.01). Chronic hepatitis level of various type increased obviously with pathology degree being severe(tablel)(F=60.08,P0.01),Effi- ciency estimated that specificity was 97.44%(114/117)and sensitivity was 90.43%(170/188).Correlation coefficients between serum TBA and Tbil,ALT,AST was a positive correlation(r=O.5032,0.2204,0.2900,Pall0.01),and GGT was no correlation (r=0.1216,P0.05),Conclusion serum TBA can reflect The hepatic function sensitively and specifically,there was important reference value for diagnosis and estimation pathology of acute and chronic hepatitis.