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Gemcitabine and Oxaliplatin Combination Chemotherapy in Patients with Advanced Non-Small-Cell Lung Cancer

Lu Jin

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Abstract

Objective: To evaluate the efficacy and toxicity of gemcitabine(GEM) and oxaliplatin(LOHP) combination chemotherapy in patients with advanced non-small-cell lung cancer.Methods: 35 patients with advanced NSCLC diagnosed pathologically were treated with the combination chemotherapy(GEM 1250 mg/m2 on day 1.8 and LOHP130 mg/m2 on day 1).Each patient was given 2 cycles at an interval of 3 weeks,and the efficacy and toxicity were then evaluated.Results: The overall response rate was 48.57%.The main toxicity was thrombocytopenia,leucocytopenia and peripheral nervous toxicity.Conclusion: The combination chemotherapy of gemcitabine and oxaliplatin is an effective chemotherapy with acceptable toxicities for advanced NSCLC.

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What this paper is about

Objective: To evaluate the efficacy and toxicity of gemcitabine(GEM) and oxaliplatin(LOHP) combination chemotherapy in patients with advanced non-small-cell lung cancer.Methods: 35 patients with advanced NSCLC diagnosed pathologically were treated with the combination chemotherapy(GEM 1250 mg/m2 on day 1.8 and LOHP130 mg/m2 on day 1).Each patient was given 2 cycles at an interval of 3 weeks,and the efficacy and toxicity were then evaluated.Results: The overall response rate was 48.57%.The main toxicity was thrombocytopenia,leucocytopenia and peripheral nervous toxicity.Conclusion: The combination chemotherapy of gemcitabine and oxaliplatin is an effective chemotherapy with acceptable toxicities for advanced NSCLC.

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Available abstract

Objective: To evaluate the efficacy and toxicity of gemcitabine(GEM) and oxaliplatin(LOHP) combination chemotherapy in patients with advanced non-small-cell lung cancer.Methods: 35 patients with advanced NSCLC diagnosed pathologically were treated with the combination chemotherapy(GEM 1250 mg/m2 on day 1.8 and LOHP130 mg/m2 on day 1).Each patient was given 2 cycles at an interval of 3 weeks,and the efficacy and toxicity were then evaluated.Results: The overall response rate was 48.57%.The main toxicity was thrombocytopenia,leucocytopenia and peripheral nervous toxicity.Conclusion: The combination chemotherapy of gemcitabine and oxaliplatin is an effective chemotherapy with acceptable toxicities for advanced NSCLC.

Key concepts: Medicine, Oxaliplatin, Gemcitabine, Chemotherapy, Toxicity, Lung cancer, Internal medicine, Oncology

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