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2016•uO Research (University of Ottawa)Open access

Slk19 inhibition of Separase inhibits anaphase onset

Laura Mai

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Abstract

Anaphase onset is triggered by the activation of Esp1/Separase, a protease that cleaves Mcd1/Scc1 subunit of the Cohesion ring complex that physically holds sister chromatids together.Separase is regulated by the anaphase inhibitor Pds1/Securin.• Anaphase onset can be monitored by the lengthening of the spindle fibers as the spindle pole bodies move apart from each other after ~20 minutes in metaphase:

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Anaphase onset is triggered by the activation of Esp1/Separase, a protease that cleaves Mcd1/Scc1 subunit of the Cohesion ring complex that physically holds sister chromatids together.Separase is regulated by the anaphase inhibitor Pds1/Securin.• Anaphase onset can be monitored by the lengthening of the spindle fibers as the spindle pole bodies move apart from each other after ~20 minutes in metaphase:

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Available abstract

Anaphase onset is triggered by the activation of Esp1/Separase, a protease that cleaves Mcd1/Scc1 subunit of the Cohesion ring complex that physically holds sister chromatids together.Separase is regulated by the anaphase inhibitor Pds1/Securin.• Anaphase onset can be monitored by the lengthening of the spindle fibers as the spindle pole bodies move apart from each other after ~20 minutes in metaphase:

Key concepts: Separase, Securin, Anaphase, Cohesin, Cell biology, Metaphase, Spindle checkpoint, Chemistry

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