2011•Jiguang zazhiRequires access
Effect of pulsed electromagnetic fields of different intensity on bone mineral density of femur in ovariectomized rats
Chengqi He
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Abstract
Objective:The purpose of this study was to observe the effect of different treatment intensity of pulsed electromagnetic fields(PEMFs) on bone mineral density of femur in ovariectomized rats,so as to find out the treatment intensity for the best therapeutic efficacy.Methods: Fifty female SD rats were randomly divided into five groups:(1) sham-operated control(no PEMFs treatment),(2) ovariectomized control(no PEMFs treatment),(3) ovariectomized I(PEMFs treatment at 8Hz frequency with 0.77mT intensity,40min daily for 30days),(4) ovariectomized II(PEMFs treatment at 8Hz frequency with 3.82mT intensity,40min daily 30 days),and(5) ovariectomized Ⅲ(PEMFs treatment at 8Hz frequency with 9.87mT intensity,40min daily 30 days).Except for 10 rats of the sham-operated control group,a standardized ovariectomy was used in every rat.Estradiol(E2) of serum and bone mineral density of femur were assessed at 30 days after PEMFs treatment.Results:The bone mineral density of the OVXo control group were significantly lower than the other 4 groups(P0.05 or P0.01),but the difference in bone mineral density was not significant among the other 4 groups(P0.05).that means OVXⅠ,OVXⅡ,OVXⅢ groups can prevent bone mineral density of femur.Conclusion:0.77mT-9.87mT magnetic intensity can prevent bone mineral density of femur ovariectomized rats effectively.