Effects of fluvastatin on exercise-induced myocardial ischemia in patients with stable exertional angina pectoris and hypercholesterolemia

AIM: To investigate the effects of fluvastatin on myocardial ischemia induced by exercise testing in patients with stable exertional angina pectoris and hypercholesterolemia. METHODS: Ninety patients with stable exertional angina pectoris,positive exercise test and hypercholesterolemia were randomly divided into a 12-week treatment period either diet plus fluvastatin(n=45) or diet alone(n=45).All the patients underwent exercise testing before and after the treatment period.RESULTS:Fluvastatin-treated patients had a significant decrease in total cholesterol,triglyccrides,high-density lipoprotein cholesterol and low-density lipoprotein cholesterol after treatment(P0.05).After treatment,the patients in the fluvastatin group had significantly increase in exercise tolerance,longer time in ST depression of 1.0 mm and decrease in the severity of ST depression.CONCLUSION: Fluvastatin can reduce exercise-induced myocardial ischemia in patients with stable exertional angina pectoris and hypercholesterolemia.