The research for the expression of TGF β_1 and E-Selectin in placenta of patients with pre-eclampsia

Objective:To study the expression of TGF β_1 and E-Selectin in placenta of patients with pre-eclampsia.Methods:20 normal pregnant women(control group) and 40 women with pre-eclampsia(pre-eclampsia group,16 women with mild pre-eclampsia and 24 women with severe pre-eclampsia) were selected.The cellular distribution of TGF β_1 and E-Selectin in placenta in both groups was determined by immunohistochemistry,and the mean density was measured by image analysis system.Results:①The level of TGF β_1 in placental villus syncytiotrophoblast of pre-eclampsia group was significantly higher than that of control group,but the level of E-Selectin in pre-eclampsia group was significantly lower than that of control group,and there were significance in statistics(P0.05).But there were no significant difference in women with mild pre-eclampsia and severe ones(P0.05).②The level of E-Selectin in placental villus capillary vascular endothelial cells of pre-eclampsia group was significantly higher than that of control group,and there was significance in statistics(P0.05),but there was no significant difference in women with mild pre-eclampsia and severe ones(P0.05).Conclusion:TGF β_1 and E-Selectin may participate in pathogenic process of pre-eclampsia.