Clinical analysis of alternate use of hypertonic saline and mannitol in treatment of postoperative intracranial hypertension in severe traumatic brain injury

Objective To explore the efficacy and safety of the alternate use of hypertonic saline and mannitol in the treatment of postoperative intracranial hypertension in severe traumatic brain injury.Methods 120 cases of postoperative intracranial hypertension in severe traumatic brain injury treated in our hospital from January 2011 to June 2013 were selected and randomly divided into observation group(alternate use of 3% hypertonic saline and 20% mannitol),hypertonic saline group(3% hypertonic saline alone) and mannitol group(20% mannitol alone).3 days after treamtment,intracranial pressure,serum creatinine and serum sodium were compared.Results Intracranial pressure of patients in the observation group 3 days after treatment was significantly lower than that in the hypertonic saline group and mannitol group(P0.05);serum sodium level of the observation group was significantly lower than that of the hypertonic saline group(P0.05);serum creatinine level of the observation group was significantly lower than that of the mannitol group(P0.05).Conclusion Altenate use of hypertonic saline and mannitol can effectively reduce intracranial pressure in severe traumatic brain injury and can also reduce the incidence of renal dysfunction and electrolyte balance disorder.