2004•Zhongguo yaoke daxue xuebaoRequires access

Preparation of Polylactic Acid Microspheres Loading Ivermectin

Xia Xiao

Abstract

AIM:To screen out the optimum formulation of poly(D,L-lactide acid)(PLA) microspheres loading Ivermectin.METHOD:The effect of molecular weight of PLA,types of emulsifier and oil phase on the preparation of microspheres was studied.Solvent evaporation technique and solvent extraction-evaporation technique were compared,and the factor of temperature on the latter method was studied.The size of microspheres was taken as an experiment index.L 9 (3 4 ) orthogonal experimental design was used to optimize the composition and technique of microspheres.RESULT:The volume average size of microspheres is 7.962±0.18μm,drug loading is 16.8%±0.5% and the encapsulation efficiency is (82.4±1.7)%.CONCLUSION:The formulation screened out is reproducible.

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Key concepts: Polylactic acid, Microsphere, Ivermectin, Solvent, Particle size, Materials science, Chromatography, Chemical engineering