Expression of Bcl-2 and Bax proteins in endometrial carcinoma cells and their clinical significance

Objective To study the expression and significance of Bcl- 2 and Bax proteins in endometrial carcinoma cells.Methods Seventy patients with endometrial carcinoma were enrolled in this study,including 29 cases of G1( grade I),23 cases of G2( grade II) and 18 cases of G3( grade III). And 20 normal endometrium tissue specimens were considered as the control group. Results The positive rate of Bcl- 2 protein expression and OD value were both higher in grade III group than in the control group and grade I group( P 0. 05),while the positive rate of Bax protein expression and OD value of grade III group were both lower than those of the control group and grade I group( P 0. 05). The positive rate of Bcl- 2 protein expression and OD value of grade II group were both higher than those of the control group( P 0. 05),while the positive rate of Bax protein expression and OD value of grade II group were both lower than those of the control group( P 0. 05). The positive rate of Bcl- 2 protein expression and OD value in endometrial carcinoma cells in post- treatment were both lower than those in pre- treatment( P 0. 05),while the positive rate of Bax protein expression and OD value in endometrial carcinoma cells in post- treatment were both higher than those in pre- treatment( P 0. 05). Conclusions Bcl- 2 and Bax proteins may reflect the differentiation degree of endometrial carcinoma in a certain extent.