Effect of ethyl pyruvate on systemic hemodynamics with septic shock in dogs

Objective To investigate the systemic hemodynamic effects of ethyl pyruvate with septic shock in dogs.Methods Twenty dogs with septic shock induced by lipopolysaccharides(LPS) were randomly divided into 2 groups.The dogs randomly received placebo(Ringer's solution;control group,n=8) or ethyl pyruvate in lactated Ringer's solution(n=12;0.05 g/kg loading dose over 10 mins,thereafter 0.05 g/kg/hr for 12h).Parameters of hemodynamics were monitored each hour after basic measurements(pre-LPS).Results After LPS infusion,mean arterial pressure(MAP) dropped significantly,but it was elevated and maintained at the baseline level in dogs treated with ethyl pyruvate,which was not found in the control group(P0.05).Although there was no statistically significant intergroup difference(P0.05),EP infusion increased cardiac output to greater than that of the control group.Central venous pressure(CVP),mean pulmonary arterial pressure(MPAP),right ventricular stroke work index(RVSWI) elevated initially in boths groups,but decreased to the lower levels in the EP group(P0.05),despite comparable fluid administration.Stroke volume index(SVI),left ventricular stroke work index(LVSWI) initially reduced markedly,but increased towards baseline level quickly,there was no difference between the 2 groups(P0.05).Systemic vascular resistance index(SVRI) reduced significantly in both groups,but increased to a higher level in EP group compared with that of control group(P0.05).On the contrary,pulmonary vascular resistance index(PVRI) elevated initially,and decreased to baseline level in EP group,whereas remained a higher level in the control animals(P0.05).Conclusion Ethyl pyruvate infusion could improve hemodynamic stability in dogs with septic shock.