Changes of monocyte chemoattractant protein-1 content in adenomyotic tissue and its significance

Objective To investigate the role of monocyte chemoattractant protein-1(MCP-1) in the pathogenesis of adenomyosis.Methods MCP-1 was examined by immunohistochemistry method and real-time PCR in the eutopic endometrium and ectopic endometrium of 36 patients with adenomyosis,and the results were compared with those of controls.Results MCP-1 contents in the eutopic endometrium and ectopic endometrium of patients with adenomyosis were significantly higher than those of normal controls(P0.05).The contents in ectopic endometrium tissue was significantly higher than that in eutopic endometrium tissue(P0.05),and the contents in the two tissues were significantly correlated with each other(r=0.87,P0.01). Conclusion MCP-1 may be involved in the pathogenesis of adenomyosis,but the specific molecular mechanisms need further study.