A New Method of Coupling Propargyl Alcohol with Merrifield Resin
Yan Zan
Abstract
Yan Zan
Abstract
A new method of coupling propargyl alcohol with Merrifield resin was investigated.Propargyl alcohol was attached to Merrifield resin employing (6-hydroxymethyl) 3,4-dihydro-pyran counpling functionality, loading level for the alcohol was 87.8% However, the propargyl alcohol could readily be cleaved from the supports with trifluoroacetic acid.
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A new method of coupling propargyl alcohol with Merrifield resin was investigated.Propargyl alcohol was attached to Merrifield resin employing (6-hydroxymethyl) 3,4-dihydro-pyran counpling functionality, loading level for the alcohol was 87.8% However, the propargyl alcohol could readily be cleaved from the supports with trifluoroacetic acid.
Key concepts: Propargyl alcohol, Propargyl, Trifluoroacetic acid, Alcohol, Hydroxymethyl, Coupling (piping), Chemistry, Materials science