Influence of Autologous Transfusion System on Systemic Inflammatory Response after Cardiopulmonary Bypass

ObjectiveTo explore the influence of autologous transfusion system (ATS) on systemic inflammatory response after cardiopulmonary bypass (CPB) in coronary artery bypass grafting (CABG).Methods Twelve patients who received CABG under CPB were randomly divided into experimental group and control group (6 in each group). In experimental group, the blood in operative field and the residual blood in circulation conduit after CPB were collected and processed with ATS, while the residual blood were retransfused directly to patients in control group. Terminal complement complex (sC 5b-9), interleukin-6 (IL-6) and other inflammatory factors were determined in two groups during perioperative period. In experimental group, inflammatory factors were determined before and after the process of ATS.ResultsThe haematocrit (HCT) of recovered blood were raised after process of ATS (P0.01), and the levels of sC 5b-9, IL-6 and TNF-α were decreased markedly (P0.05). The change ratio of sC 5b-9 were lower at 6h, 24h, 48h after CPB in experimental group than in control group (P0.05). The change ratio of IL-6 were lower at 48h after CPB in experimental group than in control group (P0.05). But there were no difference in TNF-α between two groups. The polymorphonuclear leucocyte (PMN) count were lower at 48h after CPB in experimental group than in control group (P0.01).ConclusionsThe process of ATS can remove a majority of inflammatory factors in recovered blood in CABG with CPB and transfusion of the processed blood can partly reduce the levels of inflammatory medium and relieve the inflammatory response after CPB.